Pediatric endocrinology

Socioeconomic differences in bone mass in pediatric populations: A systematic review

Osteoporos IntPublished Systematic review

Authors' conclusion

Although the evidence points to a potential direct relationship between parental education and whole-body and femoral BMD, this relationship appears to be an indirect effect, likely mediated by factors such as fat mass. For BMC, no consistent relationship with parental education was found.

Study context

Population
Children and adolescents with bone mass assessed by central DXA; five electronic databases searched8 studies included
Comparison
Bone mass by socioeconomic indicators
Outcome
Differences in BMD and BMC according to socioeconomic indicators

Pooled result

As reported in the abstract

Bone mass by parental/guardian education

Lower whole-body bone mineral density (BMD) with lower parental/guardian education

2 of 3 studies

Lower femoral BMD with lower parental/guardian education

all 8 results from 1 study

Lower whole-body BMC with lower parental/guardian education

1 of 7 possible results

Further pooled results

Other socioeconomic indicators (e.g., education, region of residence, marital status, economic level, social class)

Investigated by very limited number of studies, preventing a robust synthesis
≤ 2 studies

Original publication

Socioeconomic differences in bone mass in pediatric populations: A systematic review. Osteoporos Int. Published 29 October 2025. doi:10.1007/s00198-025-07744-2

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