A personalized approach to classify the degree of liver insulin resistance in children with obesity
Authors' conclusion
The novel LIR quantification method provides a more precise assessment of insulin resistance in paediatric obesity management compared to traditional methods. By considering individual glucose and insulin dynamics, this approach enhances risk stratification and treatment planning tailored to each patient's OGTT response curve.
Study context
- Population
- Paediatric patients with obesity undergoing oral glucose tolerance tests (OGTTs)242 OGTTs
- Comparison
- Novel personalized liver insulin resistance (LIR) quantification vs conventional LIR quantification
- Outcome
- Associations of LIR with clinical markers of obesity and T2D
Methodological detailsGlucose and insulin measured at six timepoints; liver enzymes, plasma lipids, blood pressure, height and weight obtained concurrently
- Glucose and insulin measured at six timepoints; liver enzymes, plasma lipids, blood pressure, height and weight obtained concurrently
Main finding
As reported in the abstract
- Novel approach showed stronger associations between glucose and insulin responses and clinical markers of obesity and T2D vs conventional method
- Heterogeneous OGTT response dynamics, with substantial variability in peak glucose and insulin
Original publication
A personalized approach to classify the degree of liver insulin resistance in children with obesity. Diabetes Obes Metab. Published 2 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →