Which adiposity marker is most strongly associated with all‑cause and cause‑specific mortality? a prospective study of 158,699 Mexican adults
Authors' conclusion
Waist circumference was the adiposity marker most strongly associated with all-cause and CVD mortality, even after excluding the first 10 years of follow-up.
Study context
- Population
- Adults from the Mexico City Prospective Study28,296 deaths
- Participants
- 158,699 adults
- Exposure
- BMI, waist circumference, waist-to-height ratio and WHR as adiposity markers
- Outcome
- All-cause and cause-specific mortality
- Follow-up
- Median 15.5 years
Methodological detailsCox regression, exclusion of prevalent diseases at baseline, sensitivity analyses excluding deaths in first 2, 5 and 10 years
- Cox regression
- Exclusion of prevalent diseases at baseline
- Sensitivity analyses excluding deaths in first 2, 5 and 10 years
Main finding
As reported in the abstract
All-cause mortality
- High waist circumference, excluding first 2 years: HR
- 1.83 (95% CI 1.26-2.55)
- High waist circumference, excluding first 5 years: HR
- 1.83 (95% CI 1.23-2.62)
- High waist circumference, excluding first 10 years: HR
- 1.85 (95% CI 1.14-2.70)
- Elevated WHR, excluding first 2 years: HR
- 1.71 (95% CI 1.07-2.30)
- Elevated WHR, excluding first 5 years: HR
- 1.70 (95% CI 1.05-2.49)
- Elevated WHR, excluding first 10 years: HR
- 1.71 (95% CI 1.01-2.52)
Observational data: associations, not effects.
Further findings
CVD mortality
- High waist circumference, excluding first 2 years: HR
- 4.76 (95% CI 1.70-11.82)
- High waist circumference, excluding first 5 years: HR
- 4.75 (95% CI 1.56-11.88)
- High waist circumference, excluding first 10 years: HR
- 4.73 (95% CI 1.42-12.90)
- Elevated WHR, excluding first 2 years: HR
- 2.69 (95% CI 1.10-5.60)
- Elevated WHR, excluding first 5 years: HR
- 2.66 (95% CI 1.12-5.75)
- Elevated WHR, excluding first 10 years: HR
- 2.64 (95% CI 1.03-7.32)
Respiratory and cancer mortality
- BMI, waist circumference, waist-to-height ratio and WHR not associated with respiratory and cancer mortality
Original publication
Which adiposity marker is most strongly associated with all‑cause and cause‑specific mortality? a prospective study of 158,699 Mexican adults. Int J Obes (Lond). Published 1 July 2025. doi:10.
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