Exploring insulin resistance and pancreatic function in individuals with overweight and obesity: Insights from oral glucose tolerance test (OGTTs) and IRTs
Authors' conclusion
In individuals with preobesity, there is an increase in pancreatic β-cell function to maintain normal blood glucose levels. As the disease progresses, obesity substantially increases insulin resistance, which acts as a disease-promoting factor. Furthermore, OGTT 1-h plasma glucose concentrations are strongly correlated with insulin secretion in normal or early diabetic populations.
Study context
- Population
- Overweight or obese people, categorized by OGTT results and BMI classification criteria
- Exposure
- Obese vs normal weight vs overweight individuals with similar glucose tolerance
- Outcome
- HOMA-β, HOMA-IR and ΔI30/ΔG30 among individuals with similar glucose tolerance
Main finding
As reported in the abstract
- Obese had higher HOMA-β, HOMA-IR and ΔI30/ΔG30 than normal weight and overweight
Observational data: associations, not effects.
Further findings
Correlation of OGTT 1-h plasma glucose with early insulin secretion, in normal glucose tolerance and early diabetes
- OGTT 1-h plasma glucose showed a stronger correlation with early insulin secretion across body weights
OGTT vs IRT differences by weight group in the same glucose-tolerant population
- OGTTs were significantly less different than IRTs
Original publication
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