The 1‐Hour Plasma Glucose for Early Risk Stratification in Young, Obese Chinese Adults: Implications for Clinical Management
Authors' conclusion
The IDF 1h-PG criteria uncover a substantial, previously unrecognised burden of dysglycaemia in young Chinese adults with obesity, supported by clear metabolic defects and strong diagnostic performance. These findings support the use of 1h-PG as a practical tool for earlier risk stratification in this vulnerable population.
Study context
- Population
- Young Chinese adults with obesity (aged 18–40 years, BMI ≥ 28 kg/m²) undergoing 75-g oral glucose tolerance test (OGTT)
- Participants
- 2,484 adults
- Exposure
- International Diabetes Federation (IDF) 1h-PG criteria vs American Diabetes Association (ADA) criteria
- Outcome
- Prevalence of diabetes
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Diagnostic accuracy of IDF 1h-PG cutoffs vs ADA criteria (ROC)
- AUC of IDF diabetes cutoff (11.6 mmol/L); matched the population-optimal cutoff
- 0.927
- Sensitivity of intermediate hyperglycaemia cutoff (8.6 mmol/L) for ADA-defined prediabetes
- 86.8%
Metabolic phenotype of newly identified dysglycaemic population
- Intermediate metabolic phenotype with worsening insulin resistance and impaired early-phase β-cell function
Original publication
The 1‐Hour Plasma Glucose for Early Risk Stratification in Young, Obese Chinese Adults: Implications for Clinical Management. Diabetes Obes Metab. Published 2 March 2026. doi:10.
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