A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial
Primary result · Weight-for-length trajectoryResult — go to the resultEstimated reduction 0.33 kg/m 95% CI 0.09–0.57Authors' conclusion
A health literacy-informed digital intervention improved child weight-for-length trajectory across the first 24 months of life and reduced childhood obesity at 24 months. The intervention was effective in a racially and ethnically diverse population that included groups at elevated risk for childhood obesity.
Study context
- Population
- Children enrolled shortly after birth, born after 34 weeks' gestational age, parents speaking English or Spanish; 6 US medical centers; 15.9% Black non-Hispanic, 45.0% Hispanic86.3% with 24-month primary data
- Participants
- 900 children
- Comparison
- Clinic + digital intervention vs clinic-only health behavior counseling
- Clinic + digitaln = 449
- Clinic-onlyn = 451reference
- Primary endpoint
- Child weight-for-length trajectory
- Follow-up
- Over 24 months
Methodological detailsindividually randomized, parallel-group, multicentre (6 US medical centers), Enrollment October 2019–January 2022, follow-up through January 2024
- Individually randomized
- Parallel-group
- Multicentre (6 US medical centers)
- Enrollment October 2019–January 2022, follow-up through January 2024
Primary result
Weight-for-length trajectory · 24 months
Estimated reduction
0.33 kg/m
95% CI 0.09–0.57
As reported in the abstract
Secondary outcomes
| Outcome | Clinic + digital | Clinic-only | Adjusted RR (95% CI) | |
|---|---|---|---|---|
| Overweight or obesity (CDC criteria: BMI ≥85th percentile) · age 24 months | 23.2% | 24.5% | 0.91 (0.70–1.17) | |
| Obesity · age 24 months | 7.4% | 12.7% | 0.56 (0.36–0.88) | |
| 0.20.5125Adjusted relative risk (log scale) |
Weight-for-length z score
- Adjusted mean difference, weight-for-length z score
- −0.19 (95% CI, −0.37 to −0.02)
Body mass index (BMI) z score
- Adjusted mean difference, BMI z score
- −0.19 (95% CI, −0.36 to −0.01)
Original publication
A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial. JAMA. Published 24 December 2024. doi:10.
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