Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study
Authors' conclusion
Tobacco initiation may lead to worse obesity-related traits in the general 40- to 69-year-old individuals. Therefore, tobacco-use initiation as a long-term weight-control measure should be discouraged.
Study context
- Population
- White British-ancestry UK Biobank participants aged 40–69 years; instruments: 378 genetic variants for smoking initiation from GWAS meta-analysis of 1.2 million individualsUK Biobank
- Participants
- 337,138 participants
- Comparison
- Genetically predicted smoking initiation vs not
- Outcome
- BMI, waist circumference, hip circumference and waist-to-hip ratio
Methodological detailssummary-level, inverse variance weighted, pleiotropy-robust MR (median-based, MR-Egger), replication analysis
- Summary-level
- Inverse variance weighted
- Pleiotropy-robust MR (median-based, MR-Egger)
- Replication analysis
Main finding
As reported in the abstract
Obesity-related traits with genetically predicted smoking initiation
BMI
+0.28 (0.18-0.38) kg/m²
Waist circumference
+0.88 (0.66-1.10) cm
Hip circumference
+0.40 (0.23-0.57) cm
Waist-to-hip ratio
+0.006
0.005–0.007
Further findings
BMI, replication analysis (GERA/GIANT, 364,487 samples)
- Higher BMI with genetically predicted smoking initiation
- +0.03 (0.01, 0.05] kg/m²
Original publication
Causal effects from tobacco smoking initiation on obesity-related traits: a Mendelian randomization study. Int J Obes (Lond). Published 26 August 2023. doi:10.
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