A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity
Authors' conclusion
These results suggest that liraglutide leads to weight loss without self-report or neural evidence supporting a concomitant reduction of food liking in participants with OB.
Study context
- Population
- Participants with obesity and without diabetes following a multidisciplinary weight loss programrandomized 1:1
- Participants
- 73 participants
- Comparison
- Liraglutide 3.0 mg vs placebo, subcutaneously once daily for 16 weeks
- Primary endpoint
- Self-reported liking (hedonic experience) during consumption of a high-calorie food (milkshake) vs a tasteless solution, with neural responses on Magnetic Resonance Imaging (MRI)
- Follow-up
- Pre- and post-intervention sessions
Methodological detailssingle-center, double-blind, placebo-controlled, parallel group, prospective
- Single-center
- Double-blind
- Placebo-controlled
- Parallel group
- Prospective
Primary result
As reported in the abstract
Liking during food consumption · pre- vs post-intervention
- None of the effects involving the intervention factor reached significance for liking between sessions or groups
- Liking during food reward consumption was associated with activation of the ventromedial prefrontal cortex (vmPFC) and the amygdala
Further findings
| Outcome | Liraglutide | Placebo |
|---|---|---|
| BMI change (post − pre) · 16 weeks | −3.19 ± 1.28 kg/m² | −0.60 ± 1.26 kg/m² |
BMI change (post − pre) · 16 weeks
- The liraglutide group lost more weight than the placebo group
Original publication
A randomized controlled trial investigating the effect of liraglutide on self-reported liking and neural responses to food stimuli in participants with obesity. Int J Obes (Lond). Published 25 August 2023. doi:10.
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