Exposure to written content eliciting weight stigmatization: Neural responses in appetitive and food reward regions
Authors' conclusion
Exposure to WS was associated with increased responsiveness to HC food content in the dorsal striatum and thalamus in individuals with overweight and obesity.
Study context
- Population
- Adults with overweight and obesity
- Participants
- 20 vs 20
- Comparison
- Written weight stigma article vs control article
- Weight stigma (WS)n = 20
- Controln = 20reference
- Primary endpoint
- Neural activity in food reward- and appetite-related regions in response to high-calorie (HC), low-calorie and non-food pictures
- Follow-up
- After reading the article
Methodological detailsfunctional brain imaging, a priori region of interest analyses, exploratory whole-brain analyses
- Functional brain imaging
- A priori region of interest analyses
- Exploratory whole-brain analyses
Primary result
As reported in the abstract
Activation to HC > low-calorie food cues (a priori region of interest analyses)
- Significant group differences in activation to high-calorie (HC) > low-calorie food cues in the caudate and thalamus
Further findings
Exploratory whole-brain analyses, HC > low-calorie food cues
- Significant differences in regions including left insula, left thalamus, left inferior temporal gyrus, right lingual gyrus, and bilateral middle occipital gyrus and superior parietal lobule
- P < 0.005 uncorrected, k ≥ 200 m³
Relationship of activation pattern with TFEQ, glucose and subjective appetite in WS
- No significant relationships between activation pattern and TFEQ, glucose or subjective appetite in WS
Original publication
Exposure to written content eliciting weight stigmatization: Neural responses in appetitive and food reward regions. Obesity (Silver Spring). Published 20 October 2023. doi:10.
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