Neural processing of sweet taste in reward regions is reduced following bariatric surgery
Authors' conclusion
Bariatric surgery reduces the reward system response to sweet taste in women with obesity without affecting activity in sensory regions, which is consistent with reduced drive to consume sweet foods.
Study context
- Population
- Nondiabetic bariatric surgery participants (women with obesity) and controls with normal weight to overweight21 bariatric repeated after surgery
- Participants
- 24 vs 21
- Exposure
- Bariatric participants before vs after surgery, and vs controls
- Bariatricn = 24
- Controln = 21reference
- Outcome
- Brain reward system (ventral tegmental area, ventral striatum, orbitofrontal cortex) ROI activation to sucrose
- Follow-up
- After vs before surgery
Methodological detailsfunctional MRI
- Functional MRI
Main finding
As reported in the abstract
- 0.40M sucrose activation in reward regions decreased after surgery
- 0.10M sucrose activation in reward regions did not decrease after surgery
Observational data: associations, not effects.
Further findings
Perceived sweet intensity
- Not different among control, presurgery and postsurgery groups
Preferred sweet concentration in bariatric participants · before to after surgery
- Decreased after surgery (0.52M to 0.29M)
- P = 0.008
Sensory region (primary somatosensory and primary taste cortex) activation to 0.40M sucrose
- Unchanged by surgery; did not differ between control and bariatric participants
Primary taste cortex activation to 0.10M sucrose · after surgery
- Greater in postsurgical bariatric participants vs controls
Original publication
Neural processing of sweet taste in reward regions is reduced following bariatric surgery. Obesity (Silver Spring). Published 28 August 2024. doi:10.
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