Obesity medications in patients with recurrent weight gain or suboptimal clinical response following bariatric surgery: a meta-analysis
Authors' conclusion
Our results indicated that obesity medications may be an effective adjunctive therapy to maintain weight loss post-bariatric surgery.
Study context
- Population
- Patients with recurrent weight gain or suboptimal clinical response following bariatric surgery26 studies
- Comparison
- Obesity medications (GLP-1 RA and non-GLP-1 RA) for recurrent weight gain or suboptimal clinical response after bariatric surgery
- Outcome
- Weight, BMI or percentage total weight loss (%TWL)
Methodological detailsSearch of Scopus, PubMed/Medline and Web of Science up to December 2024
- Search of Scopus, PubMed/Medline and Web of Science up to December 2024
Pooled result
As reported in the abstract
Weight, BMI and %TWL
| Group | Weight reduction | Body mass index (BMI) reduction | %TWL | Weight loss | BMI loss |
|---|---|---|---|---|---|
| GLP-1 RA | 8.38 kg (95% CI: −9.68 to −7.08) | 3.76 kg/m² (95% CI: −4.50 to −3.01) | 9.94% (95% CI: 8.34 to 11.53) | ||
| Non-GLP-1 RA | 4.50% (95% CI: 2.86 to 6.15) | 2.97 kg (95% CI: −4.00 to −1.95) | 1.41 kg/m² (95% CI: −2.28 to −0.53) |
Weight reduction
GLP-1 RA8.38 kg (95% CI: −9.68 to −7.08)
Non-GLP-1 RA— not stated in the abstract
Body mass index (BMI) reduction
GLP-1 RA3.76 kg/m² (95% CI: −4.50 to −3.01)
Non-GLP-1 RA— not stated in the abstract
%TWL
GLP-1 RA9.94% (95% CI: 8.34 to 11.53)
Non-GLP-1 RA4.50% (95% CI: 2.86 to 6.15)
Weight loss
GLP-1 RA— not stated in the abstract
Non-GLP-1 RA2.97 kg (95% CI: −4.00 to −1.95)
BMI loss
GLP-1 RA— not stated in the abstract
Non-GLP-1 RA1.41 kg/m² (95% CI: −2.28 to −0.53)
Further pooled results
%TWL, subgroup: semaglutide vs liraglutide
- Effect of semaglutide on %TWL significantly greater than that of liraglutide
Outcomes, subgroup: combination therapy vs monotherapy
- Combination therapy had more pronounced effects on outcomes than monotherapy
Original publication
Obesity medications in patients with recurrent weight gain or suboptimal clinical response following bariatric surgery: a meta-analysis. Int J Obes (Lond). Published 17 May 2025. doi:10.
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