Obesity

The intensity of exercise and inflammation markers in women with overweight & obesity: a systematic review and network meta-analysis

Int J Obes (Lond)Published Systematic review and network meta-analysis of randomised controlled trials

Authors' conclusion

There were significant differences in the effects of different exercise intensities on specific inflammatory markers in women living with overweight and obesity. Moderate-intensity exercise may be the most robust type of exercise intensity. Future studies should consider the importance of exercise duration and volume (e.g., in MET* minutes/week) to better understand the relationship between exercise intensity and inflammatory markers. The effects of combining exercise and diet on inflammatory markers in women with overweight and obesity should also be explored in greater depth.

Study context

Population
Women with overweight/obesity; Randomized Controlled Trials (RCTs) up to October 2024
Participants
3,989 women75 RCTs
Comparison
Different exercise intensities
Outcome
Inflammatory markers (TNF-α, CRP, IL-6, leptin, adiponectin)
Methodological detailsrandom-effects, frequentist framework
  • Random-effects
  • Frequentist framework

Pooled result

As reported in the abstract

Inflammatory markers

SUCRA of moderate-intensity exercise for modulating adiponectin

65.4%

Further pooled results

Subgroup analysis by exercise type

Moderate-intensity aerobic exercise (MAE) significantly reduced TNF-α
Moderate-intensity resistance training (MRT) most recommended for decreasing IL-6 and leptin
Moderate-intensity combined exercise (MCE) best for managing CRP and adiponectin

Original publication

The intensity of exercise and inflammation markers in women with overweight & obesity: a systematic review and network meta-analysis. Int J Obes (Lond). Published 16 May 2025. doi:10.1038/s41366-025-01777-7

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