Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40–65: a prospective cross-sectional study
Main finding · Metabolic phenotypesResult — go to the resultHazard ratio 1.7 95% CI 1.2–2.6Authors' conclusion
This is the first study to propose that obesity with hyperhomocysteinemia is a useful intermediate metabolism phenotype that could be used to identify obese patients at high risk for developing CAD.
Study context
- Population
- Obese patients with and without coronary artery disease (CAD) and non-CAD lean controls who consecutively underwent coronary angiography (discovery cohort), plus validation cohortsdiscovery cohort
- Participants
- 62 patients
- Exposure
- CAD obese vs Non-CAD obese vs Non-CAD leans
- Outcome
- Intermediate metabolism phenotypes among obese patients with and without CAD
Methodological detailsprospective, transcriptomics and metabolomics, discovery and validation cohorts, consecutive enrolment
- Prospective
- Transcriptomics and metabolomics
- Discovery and validation cohorts
- Consecutive enrolment
Main finding
Metabolic phenotypes
Hazard ratio
1.7
95% CI 1.2–2.6
Hcy
HR 1.7 (95% CI 1.2–2.6)
As reported in the abstract
- AUC, Hcy metabolomic (HCY-Mtb) index
- 0.819
- AUC, HCY-Mtb index plus clinical variables
- 0.877
Observational data: associations, not effects.
Original publication
Comprehensive transcriptomics and metabolomics analyses reveal that hyperhomocysteinemia is a high risk factor for coronary artery disease in a chinese obese population aged 40–65: a prospective cross-sectional study. Cardiovasc Diabetol. Published 24 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →