Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study
Main finding · TBLH BMCResult — go to the resultMean age- and height-adjusted difference 241 ± 20 g/cm²Authors' conclusion
The increase in bone mineralization in obese children does not adapt to the increase in body mass.
Study context
- Population
- Boys aged 8–18 with overweight/obesity (Pediatric Endocrinology Unit, Angers University Hospital) undergoing DXA and insulin, testosterone and IGF-1 measurements; lean comparators from NHANES
- Participants
- 249 vs 301
- Exposure
- Overweight/obese boys vs lean boys
- Obesen = 249
- Leann = 301reference
- Outcome
- TBLH BMC
Methodological detailssingle-centre, comparison with NHANES 2011-2015 reference data, path analyses
- Single-centre
- Comparison with NHANES 2011-2015 reference data
- Path analyses
Main finding
As reported in the abstract
Mean age- and height-adjusted difference
241 ± 20 g/cm²
- Total body less head (TBLH) bone mineral content (BMC) per 1 kg/m² increase in BMI, lean subjects
- +39 ± 6 g
- TBLH BMC per 1 kg/m² increase in BMI, obese subjects (P < .05 vs lean)
- + 25 ± 3 g
- TBLH BMC per 1 kg/m² increase in lean BMI (LBMI), lean and obese boys
- +78 ± 5 g
- TBLH BMC per 1 kg/m² increase in fat mass index (FMI) (decrease)
- 9 ± 3 g
Observational data: associations, not effects.
Further findings
Path analysis of factors influencing TBLH BMC
- TBLH BMC directly positively influenced by LBMI and indirectly positively by IGF-1, testosterone and insulin (mediated through height and LBMI)
- FMI indirectly influenced TBLH BMC, positively through LBMI and negatively through its negative impact on IGF-1 and testosterone
Original publication
Insufficient Bone Mineralization to Sustain Mechanical Load of Weight in Obese Boys: A Cross-Sectional Study. J Clin Endocrinol Metab. Published 2 January 2024. doi:10.
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