IGFBP-1 and IGF-I in relation to adiposity and mortality from midlife to old age in the Swedish Adoption/Twin Study of Aging
Authors' conclusion
Lower circulating IGFBP-1 concentrations are associated with increased adiposity but not change in adiposity, across the lifespan from middle to old age.
Study context
- Population
- Same-sex twins in the Swedish Adoption/Twin Study of Aging (SATSA), midlife to old age, baseline measurements from 1986IGFBP-1 n = 512
- Exposure
- Baseline fasting IGFBP-1 and IGF-I in relation to BMI, waist-to-height ratio (WHtR) and survival
- Outcome
- Adiposity (BMI, WHtR) by IGFBP-1 and IGF-I
- Follow-up
- 73 years (intercept)
Methodological detailssame-sex twins, 30-year follow-up, stratified by birth cohort, latent growth curve modeling, between-within twin models
- Same-sex twins
- 30-year follow-up
- Stratified by birth cohort
- Latent growth curve modeling
- Between-within twin models
Main finding
As reported in the abstract
Higher BMI per unit decrease in ln-IGFBP-1
1.8 kg/m²
p < 0.001
Higher WHtR per unit decrease in ln-IGFBP-1
3 cm/m
p < 0.001
Observational data: associations, not effects.
Further findings
Survival
- Neither IGFBP-1 nor IGF-I concentration predicted survival
IGFBP-1 and insulin
- IGFBP-1 correlated inversely with insulin concentrations
Trajectories with age
- BMI increased until 70-75 years then declined (quadratic model)
- WHtR continued to increase beyond 70-75 years
Original publication
IGFBP-1 and IGF-I in relation to adiposity and mortality from midlife to old age in the Swedish Adoption/Twin Study of Aging. Int J Obes (Lond). Published 5 April 2025. doi:10.
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