Association of overweight/obesity and overweight/obesity‐related metabolic dysfunction‐associated steatotic liver disease in young adults with coronary artery calcification later in life
Authors' conclusion
In this study, young adults with overweight/obesity-related MASLD have a higher risk of developing CAC by middle age. These abnormalities are only partially explained by traditional cardiovascular risk factors, and overweight/obesity-related MASLD has an independent impact on CAC. Our study provides evidence for identifying young adults at higher risk of developing subclinical atherosclerosis.
Study context
- Population
- Participants aged 28–39 years from the CARDIA study at year 10 (1995–1996), re-examined 15 years later
- Participants
- 2,274 participants
- Exposure
- Overweight/obese and overweight/obese MASLD vs lean in young adulthood
- Outcome
- CAC measured by CT
- Follow-up
- Year 25
Main finding
As reported in the abstract
CAC by middle age
Each group vs leanRelative risk (95% CI)
Overweight/obese
1.09(0.93–1.28)
Overweight/obese MASLD
1.32(1.08–1.61)
Observational data: associations, not effects.
Further findings
Abdominal aortic calcification (AAC) by middle age · year 25
- No difference between the three groups
Independent determinants of coronary artery calcification (CAC)
- Group, systolic blood pressure and group × systolic blood pressure interaction were independent determinants of CAC
- Linear regression models
Original publication
Association of overweight/obesity and overweight/obesity‐related metabolic dysfunction‐associated steatotic liver disease in young adults with coronary artery calcification later in life. Diabetes Obes Metab. Published 27 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →