Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study
Authors' conclusion
The LCD primarily reduces lower abdominopelvic SAT and VAT. Furthermore, lower abdominopelvic SAT volume was detected as a potential predictor for short-term AT loss in persons with obesity.
Study context
- Population
- Adults with obesity (mean BMI 34.08 ± 2.75 kg/m², mean age 46.3 ± 10.97 years, 49 females) undergoing an 8-week low-calorie diet
- Participants
- 81 adults
- Exposure
- Baseline vs post-8-week low-calorie diet (LCD)
- Outcome
- Change in MRI-based adipose tissue depots (VAT, SAT) and predictors of short-term AT loss
- Follow-up
- 8 weeks
Main finding
As reported in the abstract
AT loss after LCD
- Weight loss
- 11.61 ± 3.07 kg, p < 0.01
- Reductions in all magnetic resonance imaging (MRI)-based adipose tissue (AT) parameters
- p < 0.01
- Absolute SAT loss exceeded VAT loss, while relative apparent lipid loss was higher in VAT
- both p < 0.01
- Normalized baseline SAT volume in lower abdominopelvic third predicted most AT and apparent lipid losses; smaller volumes favored greater AT loss
- p < 0.01 for SAT and VAT loss and SAT apparent lipid volume loss
Observational data: associations, not effects.
Original publication
Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study. Int J Obes (Lond). Published 26 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →