Unmasking the role of hypertension in atherosclerosis among patients with obesity: a cardiometabolic dysfunction perspective
Authors' conclusion
In individuals with obesity, hypertension showed the largest effect estimate for association with subclinical atherosclerosis among evaluated cardiometabolic abnormalities and low-grade inflammation.
Study context
- Population
- Asymptomatic adults with obesity (BMI ≥ 30 kg/m²), CARFARE registry
- Participants
- 2,033 adults
- Exposure
- Individual cardiometabolic abnormalities and low-grade inflammation vs their absence
- Outcome
- Subclinical carotid-iliofemoral atherosclerosis (≥1 plaque, Mannheim criteria)
Methodological detailsregistry-based, multivariable logistic regression
- Registry-based
- Multivariable logistic regression
Main finding
As reported in the abstract
Association with subclinical atherosclerosis (multivariable analysis)
Odds ratio (95% CI)P value
Hypertension
1.88(1.44–2.44)
P < 0.0001Low HDL cholesterol
1.33(1.04–1.69)
P = 0.0225Observational data: associations, not effects.
Further findings
Atherosclerosis prevalence by metabolic status
P < 0.0001
Hypertension and subclinical atherosclerosis, parsimonious model
| Adjusted OR (95% CI) | P value | ||
|---|---|---|---|
| HypertensionSensitivity analysis | 1.97 (1.52–2.53) | P < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Overall atherosclerosis prevalence
- Overall prevalence
- 56.5% (95% CI 54.3-58.7%)
Hypertension and subclinical atherosclerosis, parsimonious model
- Magnitude and direction consistent across primary, parsimonious and Mannheim-restricted analyses
Original publication
Unmasking the role of hypertension in atherosclerosis among patients with obesity: a cardiometabolic dysfunction perspective. Int J Obes (Lond). Published 27 May 2026. doi:10.
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