MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes
Authors' conclusion
VSG reduces ectopic and regional fat and improves associated insulin sensitivity and cardiac health in adolescents with YO-T2D.
Study context
- Population
- Adolescents with youth-onset T2D undergoing vertical sleeve gastrectomy
- Exposure
- Pre-VSG vs 3–12 months post-VSG
- Outcome
- Body composition and fat depots
- Follow-up
- 12 months
Methodological detailspre-post, MRI-based, mixed-effects models
- Pre-post
- MRI-based
- Mixed-effects models
Main finding
As reported in the abstract
- Weight (kg), mean ± SD: pre vs 12 months
- 134.3 ± 5.1 to 103.3 ± 5.2
- Visceral adipose tissue (VAT) (cm³)
- 1943 ± 148 to 1248 ± 150
- Hepatic fat fraction (HFF)
- 23.2% ± 2.3% to 5.3% ± 2.3%
- PAT decrease
- 27%
- EAT decrease
- 33%
Observational data: associations, not effects.
Further findings
Homeostatic model assessment of insulin resistance (HOMA-IR) · 12 months
- HOMA-IR improved
- 7.8 ± 1.2 to 1.7 ± 1.2 (p < 0.01)
BMI, SAT, resting heart rate, left ventricular (LV) mass, cardiac output
- BMI, SAT, resting heart rate (RHR), LV mass and cardiac output (CO) decreased
- all p < 0.05
Correlations of VAT decrease
- With HFF decrease
- r = 0.70, p = 0.01
- With HOMA-IR decrease
- r = 0.60, p = 0.04
- With CO decrease
- r = 0.70, p = 0.03
Correlations of HFF decrease
- With BMI decrease
- r = 0.70, p = 0.03
- With HOMA-IR decrease
- r = 0.90, p < 0.001
- With RHR decrease
- r = 0.90, p = 0.002
- With CO decrease
- r = 0.80, p = 0.007
- With LV mass decrease
- r = 0.70, p = 0.02
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
MRI Analysis of Cardiac Fat, Abdominal Adiposity and Cardiac Function After Vertical Sleeve Gastrectomy in Youth With Type 2 Diabetes. Pediatr Obes. Published 17 November 2025. doi:10.
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