Impact of Vertical Sleeve Gastrectomy in Youth‐Onset Type 2 Diabetes: Changes in Glycemia, Insulin Sensitivity, and Secretion
Authors' conclusion
VSG in YO-T2D produces rapid and sustained improvements in weight, body composition, cardiometabolic health, Si, FFA, β-cell function, and glycemia, with most no longer needing diabetes medications.
Study context
- Population
- Youth with youth-onset T2D (YO-T2D) undergoing vertical sleeve gastrectomy (VSG)
- Exposure
- Before vs after VSG
- Outcome
- Weight, BMI and glycaemia after VSG
- Follow-up
- 3 and 12 months
Methodological detailspre- and postoperative assessments
- Pre- and postoperative assessments
Main finding
As reported in the abstract
- Weight change at 3 months (p < 0.01)
- −24.6 ± 5.2 kg
- Weight change at 12 months (p < 0.01)
- −31.0 ± 5.2 kg
- BMI change at 3 months (p < 0.01)
- −8.5 ± 2.0 kg/m²
- BMI change at 12 months (p < 0.01)
- −10.8 kg/m²
- Weight and BMI fell, respectively
- 18% and 23%
- HbA1c, 3 months (p = 0.003)
- 6.6% ± 0.2% to 5.7% ± 0.2%
Observational data: associations, not effects.
Further findings
Body composition · 12 months
- Body fat decrease (p = 0.01)
- 6.4%
- Fat mass decrease (p = 0.01)
- 16.8 ± 4.7 kg
Mixed-meal tolerance test (MMTT) hormones and metabolic markers · 3 months
- MMTT-stimulated GLP-1, PYY, insulin and C-peptide secretion increased; insulin clearance, glucose, free fatty acids (FFA), LDL, TG, Adipo-IR, liver transaminases and HOMA-IR decreased
Insulin sensitivity, β-cell function and cardiometabolic measures · 12 months
- Participants off diabetes medications
- 86%
- MMTT insulin, C-peptide and GLP-1 responses attenuated; insulin clearance increased; muscle-predominant sensitivity (Si), β-cell function, resting heart rate, systolic blood pressure and HDL improved; 3-month improvements persisted
Original publication
Impact of Vertical Sleeve Gastrectomy in Youth‐Onset Type 2 Diabetes: Changes in Glycemia, Insulin Sensitivity, and Secretion. Obesity (Silver Spring). Published 18 February 2026. doi:10.
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