Glycemic Normalization Immediately Following Vertical Sleeve Gastrectomy in Adolescents With Type 2 Diabetes From the ST 2 OMP Study
Authors' conclusion
Adolescents with type 2 diabetes experience early glycemic normalization post-VSG, even before major weight loss.
Study context
- Population
- Adolescents with T2D in the ST2OMP study; VSG: mean age 17.6 years, 67% female, HbA1c 7.2%, BMI 50.0 kg/m²; Advanced medical therapy (AMT): mean age 16.9 years, 53% female, HbA1c 7.8%, BMI 42.2 kg/m²
- Participants
- 73 adolescents
- Exposure
- Post-VSG vs advanced medical therapy
- Outcome
- Immediate post-VSG glycemic patterns by CGM
- Follow-up
- 14 days of CGM
Main finding
As reported in the abstract
Mean glucose
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | VSG | AMT | P value |
|---|---|---|---|
| CGM GMIMean | 5.3% | 6.9% | P < 0.001 |
| Mmol/mol | 34 | — not stated in the abstract | |
| Nmol/mol | — not stated in the abstract | 52 |
— not stated in the abstract
Continuous glucose monitoring (CGM) glucose management indicator (GMI)
- GMI normal post-VSG vs in the diabetes range with AMT
Predictors of postoperative glucose metrics
- After BMI adjustment, preoperative HbA1c predicted postoperative glucose metrics
Safety
| Outcome | P value |
|---|---|
| Time <70, <55 and <45 mg/dLVSG vs AMT | all p < 0.01 |
Time <70, <55 and <45 mg/dL
- VSG participants spent more time <70, 55 and 45 mg/dL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Glycemic Normalization Immediately Following Vertical Sleeve Gastrectomy in Adolescents With Type 2 Diabetes From the ST 2 OMP Study. Diabetes Obes Metab. Published 8 June 2026. doi:10.
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