Effects of Liraglutide on Energy Intake in Adolescents With Persistent Obesity After Vertical Sleeve Gastrectomy
Authors' conclusion
In adolescents post-VSG treated with liraglutide, overall food intake decreased without significant changes in macronutrient composition.
Study context
- Population
- Adolescents with obesity ≥1 year post-vertical sleeve gastrectomy (VSG); mean age 18.1 ± 2.0 years, BMI 40.4 ± 7.3 kg/m²completed both buffet meals
- Participants
- 27 adolescents
- Primary endpoint
- Change in energy intake (∆EI) at a standardised buffet meal after a 2-h OGTT
- Follow-up
- Baseline to 4 months
Methodological detailssingle-group, pre-post
- Single-group
- Pre-post
Primary result
As reported in the abstract
Change in mean energy intake (∆EI), standardised buffet meal after 2-h OGTT · baseline to after 4 months of liraglutide
Mean energy intake decreased
161.7 ± 264.3 kcal
p = 0.04
Further findings
Change in food mass · baseline to after 4 months of liraglutide
- Food mass decreased
- 72.5 ± 123.4 g (p = 0.02)
Macronutrient intake
- Proportional reductions in absolute macronutrient intake but no change in macronutrient distribution
Associations with ∆EI or body weight change
- Neither liraglutide AUC (n = 17) nor oral glucose tolerance test (OGTT) outcomes significantly associated with ∆EI or changes in body weight
Original publication
Effects of Liraglutide on Energy Intake in Adolescents With Persistent Obesity After Vertical Sleeve Gastrectomy. Pediatr Obes. Published 31 July 2026. doi:10.
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