The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks
Authors' conclusion
In this study sample, perinatal chemical exposures and the epigenome have low utility in predicting childhood adiposity, beyond known clinical risk factors.
Study context
- Population
- Mother-offspring pairs with perinatal clinical risk factors, cord blood per/polyfluoroalkyl substances (PFAS) and cord blood DNA methylation; children at median age 4.6 years
- Participants
- 268 mother-offspring pairs
- Outcome
- Predictive performance for childhood adiposity: BMIz (% variability explained) and fourth vs first quartile of %FM (AUC)
- Follow-up
- Median age of 4.6 years
Methodological detailssparsity ranked LASSO penalized regression, cross-validation for model tuning, split-sample validation
- Sparsity ranked LASSO penalized regression
- Cross-validation for model tuning
- Split-sample validation
Performance
As reported in the abstract
Prediction of childhood adiposity (validation set)
Optimal BMIz model: variability explained; included only clinical characteristics (maternal pre-pregnancy BMI, paternal BMI, gestational weight gain, physical activity during pregnancy, child race/ethnicity)
19.1%
Optimal model for fourth vs first quartiles of %fat mass (FM): AUC (± as printed); clinical features strongest predictors
0.82 ± 0.01
Further findings
Child adiposity measures
- BMIz, mean ± SD
- 0.01 ± 1.1
- %FM, mean ± SD
- 19.8 ± 6.34%
Original publication
The predictive utility of the in utero exposome for childhood adiposity in independent and integrated frameworks. Pediatr Obes. Published 26 September 2024. doi:10.
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