Exploring mitochondrial heteroplasmy in neonates: implications for growth patterns and overweight in the first years of life
Authors' conclusion
Our findings, based on mitochondrial DNA genotyping, offer insights into the molecular machinery leading to rapid growth in early life, potentially explaining a working mechanism of the development toward childhood overweight.
Study context
- Population
- Mother-child pairs of the ENVIRONAGE birth cohort; cord blood whole mitochondrial genome sequencing
- Participants
- 200 mother-child pairs
- Exposure
- Cord blood mitochondrial DNA (mtDNA) heteroplasmy and rapid growth and childhood overweight
- Outcome
- Rapid growth (difference between WHO-SD scores of predicted weight and birth weight) and childhood overweight
- Follow-up
- 6 and 12 months; 4-6 years
Methodological detailsENVIRONAGE birth cohort
- ENVIRONAGE birth cohort
Main finding
As reported in the abstract
Rapid growth per 1% increase in VAF of cord blood MT-D-Loop16362T > C heteroplasmy · 6 and 12 months
Rapid growth at 6 months, OR
1.03
95% CI 1.01–1.05p = 0.001
Rapid growth at 12 months, OR
1.02
95% CI 1.00–1.03p = 0.02
Observational data: associations, not effects.
Further findings
Childhood overweight per 1% increase in VAF of MT-D-Loop16362T > C · 4-6 years
- Childhood overweight, OR
- 1.01 (95% CI 1.00-1.02; p = 0.05)
Rapid growth and childhood overweight · 4-6 years
- Rapid growth at 6 months, OR for overweight
- 3.00 (95% CI 1.49-6.14; p = 0.002)
- Rapid growth at 12 months, OR for overweight
- 4.05 (95% CI 2.06-8.49; p < 0.001)
Determinants of cord blood MT-D-Loop16362T > C heteroplasmy
- Maternal age, pre-pregnancy BMI, maternal education, parity and gestational age identified as determinants
Original publication
Exploring mitochondrial heteroplasmy in neonates: implications for growth patterns and overweight in the first years of life. Int J Obes (Lond). Published 27 May 2024. doi:10.
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