Lipids & metabolic liver disease
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial
Authors' conclusion
Our results suggest that an improvement in modulation of AGE metabolism, which facilitates better management of circulating AGE levels, may be one of the mechanisms through which the Mediterranean diet, compared to a low-fat diet, reduces the progression of atherosclerosis in patients with CHD.
Study context
- Population
- Patients with coronary heart disease (CHD), divided into Non-increased IMT-CC (reduced or unchanged after dietary intervention) and Increased IMT-CC patients
- Participants
- 1,002 patients
- Comparison
- Mediterranean diet vs low-fat diet
- Primary endpoint
- Serum AGE levels (MG, CML), AGE metabolism parameters (AGER1 and GloxI mRNA, sRAGE) and GSH levels
- Follow-up
- 5 years
Primary result
As reported in the abstract
Serum MG levels
- Low-fat diet significantly increased MG vs baseline
- p = 0.029
Further findings
AGE metabolism (AGER1, GloxI expression, GSH, sRAGE), Non-increased IMT-CC subgroup · 5 years
- Mediterranean diet, but not low-fat diet, increased AGER1 and GloxI gene expression and GSH and sRAGE levels (all p < 0.05)
MG levels, Increased IMT-CC subgroup · 5 years
- Mediterranean diet increased MG, but the increment was lower than with low-fat diet (all p < 0.05)
Original publication
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial. Cardiovasc Diabetol. Published 14 October 2024. doi:10.
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