Telomere length as biomarker of nutritional therapy for prevention of type 2 diabetes mellitus development in patients with coronary heart disease: CORDIOPREV randomised controlled trial
Primary result · Incident T2DResult — go to the resultHazard ratio 1.65Authors' conclusion
Patients with shorter TL presented a higher risk of developing T2DM. This association could be mitigated with a specific dietary pattern, in our case a Mediterranean diet, to prevent T2DM in patients with coronary heart disease.
Study context
- Population
- Patients with established coronary heart disease (aged 20–75 years) without T2D at baseline, Reina Sofia University Hospital, Córdoba, Spain462 without T2DM analysed
- Participants
- 1,002 patients
- Comparison
- Short telomeres (Telomere Length (TL) < percentile 20th) vs no risk of short telomeres; Mediterranean diet vs low-fat diet
- Mediterranean dietn = 502
- Low-fat dietn = 500
- Primary endpoint
- Incident T2D
- Follow-up
- Median of 60 months
Methodological detailssingle-centre, clinical investigators masked; participants not
- Single-centre
- Clinical investigators masked; participants not
Primary result
As reported in the abstract
Hazard ratio
1.65
p-value 0.023
- Patients developed T2D
- 107
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident T2D, low-fat diet subgroupShort telomeresvs No risk of short telomeresLow-fat diet | 2.43 (1.26–4.69) | p-value 0.008 | |
| 0.20.5125Hazard ratio (log scale) |
Incident T2D, Mediterranean diet subgroup
- No differences between short telomeres and no risk of short telomeres in the Mediterranean diet group
Original publication
Telomere length as biomarker of nutritional therapy for prevention of type 2 diabetes mellitus development in patients with coronary heart disease: CORDIOPREV randomised controlled trial. Cardiovasc Diabetol. Published 16 March 2024. doi:10.
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