Lipids & metabolic liver disease
Lean Indian patients with non-alcoholic fatty liver disease (NAFLD) have less metabolic risk factors but similar liver disease severity as non-lean patients with NAFLD
Authors' conclusion
Although metabolic co-morbidities are less common, there is no difference in liver disease severity among both groups.
Study context
- Population
- NAFLD patients over last 10 years; Indian patients
- Participants
- 1,040 participants
- Exposure
- Lean vs non-lean NAFLD
- Leann = 149
- Non-leann = 891reference
- Outcome
- Clinicopathological profile and liver disease severity
Main finding
As reported in the abstract
Liver disease severity (non-invasive: FAST, FIB-4, LSM)
- FibroScan-AST (FAST), FIB-4 and liver stiffness measurement (LSM) were similar between lean and non-lean
- Between Lean and Non-lean: P = 0.53
- Between Lean and Non-lean: P = 0.94
- Between Lean and Non-lean: P = 0.19
Observational data: associations, not effects.
Further findings
DM
P > 0.99
Elevated TG
P = 0.33
Low HDL
P = 0.18
Central obesity
P < 0.001
Hypertension
P < 0.001
Metabolic syndrome
P < 0.001
NASH on biopsy
P = 0.51
Significant fibrosis on biopsy
P = 0.25
Advanced fibrosis on biopsy
P = 0.47
- NASH on biopsy: biopsy in 149 (lean 19, non-lean 130)
Original publication
Lean Indian patients with non-alcoholic fatty liver disease (NAFLD) have less metabolic risk factors but similar liver disease severity as non-lean patients with NAFLD. Int J Obes (Lond). Published 20 July 2023. doi:10.
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