Non-obese or lean non-alcoholic fatty liver disease was associated with increased risk of cancer in patients with type 2 diabetes mellitus
Main finding · Prevalence of cancerResult — go to the resultAdjusted odds ratio 5.969 95% CI 1.349–26.413Authors' conclusion
NAFLD, even non-obese or lean NAFLD, was independently associated with increased risk of cancer in patients with T2DM. Screening and management of NAFLD, especially for those with underweight or normal weight, should be strengthened from the perspective of improving prevention and management of cancer in patients with T2DM.
Study context
- Population
- Patients with T2D, Xiamen, China
- Participants
- 233 patients
- Exposure
- Non-alcoholic fatty liver disease (NAFLD) vs no NAFLD
- Outcome
- Cancer (all types)
Methodological detailscross-sectional analysis of baseline cohort data
- Cross-sectional analysis of baseline cohort data
Main finding
Prevalence of cancer
Adjusted odds ratio
5.969
95% CI 1.349–26.413
P = 0.019
By group
NAFLDvs No NAFLD
aOR 5.969 (95% CI 1.349–26.413); P = 0.019
As reported in the abstract
- Cancer diagnosed, all patients
- 19 (8.2%)
Observational data: associations, not effects.
Further findings
Prevalence of cancer by BMI category — between Underweight or normal weight and Overweight
P = 0.258
| Outcome | Estimate | P value | |
|---|---|---|---|
| NAFLD and cancer, non-obese or lean subgroup | aOR 17.446 (95% CI 1.690–180.095) | P = 0.016 | |
| NAFLD and cancer, overweight subgroup | OR 11.642 (95% CI 0.832–162.963) | P = 0.068 | |
| NAFLD and cancer, obesity subgroup | OR 0.917 (95% CI 0.170–4.954) | P = 0.920 | |
| 0.050.21520Ratio (log scale) |
- Prevalence of cancer by body mass index (BMI) category: across BMI categories (n=74, 51, 108); not significantly different
FIB-4 score and BMI vs cancer
- FIB-4 score not significantly associated with cancer risk, overall or by BMI category
- BMI not significantly associated with cancer risk, overall or stratified by NAFLD
Original publication
Non-obese or lean non-alcoholic fatty liver disease was associated with increased risk of cancer in patients with type 2 diabetes mellitus. BMJ Open Diabetes Res Care. Published 15 February 2023. doi:10.
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