Lipids & metabolic liver disease
Associations between steatotic liver disease subtypes and incident atrial fibrillation in young adults: a nationwide cohort study
Authors' conclusion
SLD is associated with new-onset AF, with a progressively increased risk across MASLD, MetALD, and ALD subtypes in young adults. Given the modifiable nature of these risks, early interventions are essential to prevent long-term cardiovascular complications and reduce the future disease burden.
Study context
- Population
- Young adults aged 20–39 years who underwent health screening 2009–2012, Korean National Health Insurance Service; mean age 30.9 years, 59.4% male
- Participants
- 6,375,710 adults
- Exposure
- Steatotic liver disease (SLD) subtypes vs non-SLD
- Outcome
- Incident AF
- Follow-up
- Median 10.6 years
Methodological detailsCox proportional hazards models
- Cox proportional hazards models
Main finding
As reported in the abstract
Each group vs Non-SLDAdjusted hazard ratio (95% CI)
MASLD
1.09(1.05–1.31)
MetALD
1.29(1.22–1.36)
ALD
1.52(1.41–1.65)
Observational data: associations, not effects.
Further findings
Prevalence of SLD and subtypes
- SLD prevalence
- 27.8%
- MASLD among SLD
- 81.7%
- MetALD among SLD
- 13.5%
- ALD among SLD
- 4.7%
Original publication
Associations between steatotic liver disease subtypes and incident atrial fibrillation in young adults: a nationwide cohort study. Cardiovasc Diabetol. Published 25 August 2025. doi:10.
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