Lipids & metabolic liver disease
Magnesium Depletion, Metabolic Impairment, and Cardiac Alterations: The NAKO-MRI Study With Mendelian Randomization
Authors' conclusion
Magnesium depletion may serve as an early indicator of cardiac impairment. However, Mendelian Randomization results do not support a causal role of serum magnesium on cardiac structure and morphology.
Study context
- Population
- Participants from the baseline examination of the German National Cohort who underwent whole-body magnetic resonance imaging (MRI)
- Participants
- 9,568 participants
- Exposure
- Serum magnesium and magnesium depletion score (MDS) vs metabolic syndrome (MetS) and MRI-derived cardiac alterations
- Outcome
- Associations of serum magnesium and MDS with MetS and cardiac alterations
Methodological detailspopulation-based, two-sample Mendelian randomization
- Population-based
- Two-sample Mendelian randomization
Main finding
As reported in the abstract
Serum magnesium per 1-SD increase: OR for MetS prevalence
0.93
95% CI 0.88–0.99
MDS per 1 unit: OR for MetS prevalence
1.32
95% CI 1.23–1.41
Higher MDS: left ventricular remodeling index, estimate
0.012 g/mL
95% CI 0.008–0.017
Higher MDS: left ventricular end-diastolic volume, estimate (concentric hypertrophy)
−1.132 mL/m²
95% CI −1.538 to −0.727
Observational data: associations, not effects.
Further findings
Correlation between serum magnesium and MDS
- No correlation, Spearman's rho
- 0.065 (P < .001)
Two-sample Mendelian randomization: serum magnesium and MRI-derived cardiac markers
- No causal relationship suggested
Original publication
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