Lipids & metabolic liver disease
Early childhood adiposity, lifestyle and gut microbiome are linked to steatotic liver disease development in adolescents
Authors' conclusion
Adiposity in early childhood and a low dietary fiber intake may contribute to the pathogenesis of SLD during adolescence, possibly through alterations to the intestinal microbiome; these findings could inform early disease markers and targets for intervention.
Study context
- Population
- Adolescents aged 14–17 years from the 13-year Growth and Obesity Cohort Study; anthropometry ages 4–17, lifestyle at 14–17, fecal microbiome by 16S rRNA sequencingmatched case-control
- Participants
- 69 vs 69
- Comparison
- Adolescents with steatotic liver disease (SLD) vs without SLD
- SLDn = 69
- Controln = 69reference
- Outcome
- Factors associated with SLD development in adolescence
Methodological detailsmatched for BMI-z scores, sex and age, 13-year longitudinal cohort
- Matched for BMI-z scores, sex and age
- 13-year longitudinal cohort
Main finding
As reported in the abstract
Higher daily fiber intake in adolescence associated with lower odds of SLD (aOR)
0.91
Bacteroides vulgatus abundance higher in controls than cases (control/case abundance ratio)
18.71
Observational data: associations, not effects.
Further findings
B. vulgatus correlations
- B. vulgatus abundance positively correlated with dietary fiber intake and inversely with childhood adiposity
Principal component analysis
- Dietary intake and childhood adiposity factors expanded distribution variation between case and control groups
Original publication
Early childhood adiposity, lifestyle and gut microbiome are linked to steatotic liver disease development in adolescents. Int J Obes (Lond). Published 12 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →