Lipids & metabolic liver disease
Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China
Authors' conclusion
Considering the risk of all-cause mortality and cause-specific mortality, we recommended 100 to 159 mg/dL as the optimal range of LDL-C among older adults in China.
Study context
- Population
- Adults aged 65 or older in Shenzhen Healthy Aging Research 2018–2019, China; vital status by December 31, 20215,333 deaths
- Participants
- 211,290 adults
- Exposure
- Low-density lipoprotein cholesterol (LDL-C) categories vs reference LDL-C 100 to 129 mg/dL
- Outcome
- All-cause mortality
- Follow-up
- Median 3.08 years
Methodological detailsrepresentative sample, multivariable Cox proportional hazards models, restricted cubic spline (RCS)
- Representative sample
- Multivariable Cox proportional hazards models
- Restricted cubic spline (RCS)
Main finding
As reported in the abstract
- All-cause mortality risk significantly higher with very low (<70 mg/dL) or low (70-99 mg/dL) LDL-C vs LDL-C 100 to 129 mg/dL
Observational data: associations, not effects.
Further findings
| Outcome | Multivariable-adjusted HR |
|---|---|
| CVD-specific mortalityVery low vs Reference | 1.338 |
| CVD-specific mortalityHigh vs Reference | 1.437 |
| CVD-specific mortalityVery high vs Reference | 1.489 |
- Cardiovascular disease (CVD)-specific mortality — CVD deaths
- 2037
Cancer mortality
- Cancer deaths
- 1881
- Low LDL-C (70-99 mg/dL) associated with increased cancer mortality
Other-cause mortality
- Very low LDL-C (<70 mg/dL) associated with increased other-cause mortality
RCS analysis
- RCS curve showed similar results
Original publication
Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China. J Clin Endocrinol Metab. Published 4 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →