Lipids & metabolic liver disease
High High-sensitivity C-reactive Protein (hsCRP) Concentration Is Associated With Acute Pancreatitis in Multifactorial Chylomicronemia Syndrome
Authors' conclusion
This retrospective study showed for the first time that hsCRP concentration is strongly associated with acute pancreatitis prevalence in MCS. It also suggests that low-grade inflammation may be a driver of acute pancreatitis in severe hypertriglyceridemia. Prospective studies could help determine the causality of this association and assess whether medication known to reduce low-grade inflammation could help prevent acute pancreatitis in individuals with severe hypertriglyceridemia.
Study context
- Population
- Subjects with multifactorial chylomicronemia syndrome (MCS) with hsCRP measured at first visit, Montreal Clinical Research Institute
- Participants
- 102 subjects
- Exposure
- MCS with vs without previous acute pancreatitis
- Outcome
- Association of low-grade inflammation (hsCRP) with acute pancreatitis
Main finding
As reported in the abstract
- High hsCRP (≥ 3 mg/L) independently associated with acute pancreatitis prevalence
- P < .05
Observational data: associations, not effects.
Further findings
Variability in acute pancreatitis prevalence explained by maximal triglycerides (TG), hsCRP, rare variants in TG-related genes and fructose intake (stepwise multivariate regression)
- Variability explained
- Up to 64%; P < .0001
Original publication
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