Association of device measured physical activity with liver fat and stiffness in people with type 1 diabetes
Authors' conclusion
Promoting PA, particularly MVPA, in T1D may help with the maintenance of liver health.
Study context
- Population
- People with T1D attending clinics or in ongoing research at the Dasman Diabetes Institute, Kuwait; mean age 40.3(14.3) years, mean body mass index (BMI) 28.8(4.8) kg/m², mean HbA1c 7.7(1.3) %, 52% male
- Participants
- 173 people
- Outcome
- Association of PA metrics (wrist-worn accelerometer, 7 days) with liver fat fraction (MRI) and liver stiffness (elastography)
Main finding
As reported in the abstract
Associations of PA with liver fat and stiffness, adjusted for age, sex and BMI
- Overall physical activity (PA) vs liver fat fraction
- B = −0.09, p = 0.04
- Overall PA vs liver stiffness
- B = −0.02, p < 0.001
- Intensity gradient vs liver stiffness
- B = −0.40, p = 0.01
- Light PA vs liver stiffness
- B = −0.001, p = 0.04
- Moderate to vigorous physical activity (MVPA) vs liver stiffness
- B = −0.003, p = 0.001
Observational data: associations, not effects.
Further findings
Associations of PA with liver enzymes, adjusted for age, sex and BMI
- Overall PA vs AST
- B = −0.23, p = 0.03
- Overall PA vs GGT
- B = −0.50, p = 0.03
- MVPA vs AST
- B = −0.06, p = 0.01
- MVPA vs GGT
- B = −0.10, p = 0.02
Associations after mutual adjustment
- Overall PA vs liver fat
- B = −0.13, p = 0.01
- Overall PA vs liver stiffness
- B = −0.01, p = 0.01
- Overall PA vs ALT
- B = −0.38, p = 0.04
- No associations remained with the intensity gradient
- Mutual adjustment
Original publication
Association of device measured physical activity with liver fat and stiffness in people with type 1 diabetes. Diabetes Obes Metab. Published 14 July 2025. doi:10.
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