Differences in the Glucose Management Indicator Between Continuous Glucose Monitoring Systems
Authors' conclusion
The relationship between mean sensor glucose and HbA1c differed between contemporary CGM systems. This finding suggests that device-specific GMI equations may improve interpretation of glycaemic control in the absence of standardisation across contemporary CGM systems.
Study context
- Population
- Adults with Type 1 diabetes using Dexcom G6/G7 or Medtronic Guardian 4/Simplera continuous glucose monitoring (CGM) systems, with 2 months of CGM data preceding HbA1c measurement
- Participants
- 252 vs 180
- Exposure
- Device-specific glucose management indicator (GMI) equations derived using linear regression of measured HbA1c on mean sensor glucose and compared with the original GMI equation
- Dexcom (Dx)n = 252
- GSin = 180
- Outcome
- Dx GMI equation vs original GMI equation
Main finding
As reported in the abstract
- Statistically significantly lower GMI values with the Dx GMI equation compared with the original GMI equation at mean sensor glucose levels < 13.7 mmol/L, with increasing differences at lower glucose levels
Observational data: associations, not effects.
Further findings
GSi GMI equation vs original GMI equation
- At mean sensor glucose levels above 8.3 mmol/L, the GSi GMI equation yielded statistically significantly higher GMI values than the original GMI equation, with increasing differences at higher glucose levels
Dx vs GSi device-specific GMI equations
- Statistically significantly different GMI values > 6.7 mmol/L, with increasing differences at higher glucose levels
Original publication
Differences in the Glucose Management Indicator Between Continuous Glucose Monitoring Systems. Diabetes Obes Metab. Published 5 November 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →