Comparison of Blood Glucose Values Used for Impending Non-Severe Hypoglycemia Management with Corresponding Continuous Glucose Monitoring Data in Type 1 Diabetes: A Secondary Analysis of the REVERSIBLE Trial
Authors' conclusion
When using CGM, PwTID may need to treat or prevent NS hypoglycemia at a higher threshold than 72 mg/dL (4.0 mmol/L) and 80 mg/dL (4.5 mmol/L), respectively.
Study context
- Population
- People living with T1D
- Comparison
- Continuous glucose monitoring (CGM) values vs corresponding blood glucose (BG) values at 3 treatment thresholds for impending non-severe (NS) hypoglycemia
Methodological detailsthree-arm, open-label, crossover
- Three-arm
- Open-label
- Crossover
Primary result
As reported in the abstract
CGM (DexcomG6) vs BG
- In all three arms CGM values overestimated BG levels
- P < 0.001
Safety
Rebound hyperglycemia (BG > 180 mg/dL; 10 mmol/L)
- No rebound hyperglycemia observed
Original publication
Comparison of Blood Glucose Values Used for Impending Non-Severe Hypoglycemia Management with Corresponding Continuous Glucose Monitoring Data in Type 1 Diabetes: A Secondary Analysis of the REVERSIBLE Trial. Diabetes Technol Ther. Published 30 September 2026. doi:10.
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