Iron overload is closely associated with metabolic dysfunction‐associated fatty liver disease in type 2 diabetes
Authors' conclusion
MAFLD is associated with significant iron overload in Chinese patients with T2DM. Serum iron, ferritin, total iron-binding capacity, hepcidin, and R 2 * value are essential iron metabolism markers to evaluate and predict the progression of MAFLD in patients with T2DM.
Study context
- Population
- Chinese inpatients with T2D; MAFLD diagnosed and grouped by magnetic resonance imaging (MRI)
- Participants
- 155 inpatients
- Exposure
- T2D with MAFLD vs T2D without MAFLD
- Outcome
- Association of iron overload (iron metabolism markers) with MAFLD
Methodological detailsMRI biomarkers measured: proton density fat fraction and iron accumulation (R2*)
- MRI biomarkers measured: proton density fat fraction and iron accumulation (R2*)
Main finding
As reported in the abstract
Iron metabolism markers (MRI-R2*, ferritin, serum iron, hepcidin, total iron-binding capacity) and MAFLD
- Iron metabolism markers overloaded in groups with MAFLD (p for trend)
- p < 0.001 for trend
- Logistic regression: the five markers revealed increased MAFLD risk (p for trend)
- p < 0.001 for trend
Observational data: associations, not effects.
Original publication
Iron overload is closely associated with metabolic dysfunction‐associated fatty liver disease in type 2 diabetes. Obesity (Silver Spring). Published 6 February 2025. doi:10.
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