Lipids & metabolic liver disease
Evidence from two large prospective cohorts: variations in remnant cholesterol inflammation index and the risk of cardiometabolic multimorbidity in middle-aged and elderly populations
Authors' conclusion
By integrating lipid and inflammatory pathways, the RCII was significantly associated with incident CMM
Study context
- Population
- Middle-aged and elderly participants of China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA); Remnant cholesterol inflammation index (RCII) = residual cholesterol (RC) (mg/dL) × high-sensitivity C-reactive protein (hs-CRP) (mg/L) / 10subcohort n = 5,966
- Participants
- 5,870 vs 2,295
- Exposure
- Per ln-unit increase in remnant cholesterol inflammation index
- CHARLSn = 5,870
- ELSAn = 2,295
- Outcome
- Incident cardiometabolic multimorbidity (CMM)
Methodological detailstwo large prospective cohorts (CHARLS and ELSA), longitudinal subcohort analysis
- Two large prospective cohorts (CHARLS and ELSA)
- Longitudinal subcohort analysis
Main finding
As reported in the abstract
CMM risk per ln-unit increase in baseline RCII
Hazard ratio (95% CI)
CHARLS
1.14(1.09–1.19)
ELSA
1.21(1.10–1.34)
Per ln-unit increase in baseline RCII, as printed
Observational data: associations, not effects.
Further findings
Cardiometabolic multimorbidity (CMM) risk with cumulative RCII increments
| HR (95% CI) | ||
|---|---|---|
| CHARLS | 1.20 (1.11–1.29) | |
| ELSA | 1.30 (1.11–1.51) | |
| 0.512Hazard ratio (log scale) |
RCII transition patterns
- Stable high RCII conferred the highest CMM risk vs stable low RCII
Predictive capability
- RCII showed moderate independent predictive capability for CMM and outperformed RC or hs-CRP alone
Original publication
Evidence from two large prospective cohorts: variations in remnant cholesterol inflammation index and the risk of cardiometabolic multimorbidity in middle-aged and elderly populations. Diabetes Res Clin Pract. Published 18 July 2026. doi:10.
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