Lipids & metabolic liver disease
Cross-national associations of atherogenic index of plasma and frailty with cardiometabolic multimorbidity: evidence from China, England, and Europe
Authors' conclusion
Frailty and combined AIP-frailty measures were associated with incident CMM across three ageing cohorts from China, England, and Europe.
Study context
- Population
- Participants aged ≥50 years and free of Cardiometabolic Multimorbidity (CMM) at baseline in the China Health and Retirement Longitudinal Study (CHARLS), the English Longitudinal Study of Ageing (ELSA), and the Survey of Health, Ageing and Retirement in Europe (SHARE)participants across three cohorts
- Participants
- 25,876 participants
- Exposure
- Higher vs lower atherogenic index of plasma (AIP), frailty index (FI), multiplicative AIP-frailty index (AIPFI), and additive AIP-plus-frailty score
- Outcome
- Incident CMM events
- Follow-up
- During
Methodological detailsCox regression models, cohort-specific estimates combined using random-effects meta-analysis, pooled two-stage analyses
- Cox regression models
- Cohort-specific estimates combined using random-effects meta-analysis
- Pooled two-stage analyses
Main finding
As reported in the abstract
Incident CMM events
1364
Observational data: associations, not effects.
Further findings
Incident CMM by higher FI
| HR (95% CI) | ||
|---|---|---|
| Higher FIPooled two-stage analysis | 1.33 (1.20–1.47) | |
| 0.512Hazard ratio (log scale) |
Incident CMM by higher AIPFI
| HR (CI) | ||
|---|---|---|
| Higher AIPFIPooled two-stage analysis | 1.30 (1.21–1.40) | |
| 0.512Hazard ratio (log scale) |
Incident CMM by higher additive AIP-plus-frailty score
| HR (CI) | ||
|---|---|---|
| Higher additive AIP-plus-frailty scorePooled two-stage analysis | 1.44 (1.27–1.63) | |
| 0.512Hazard ratio (log scale) |
Incident CMM by AIP
| HR (95% CI) | ||
|---|---|---|
| AIPPooled estimate imprecise and heterogeneous | 1.27 (0.99–1.63) | |
| 0.512Hazard ratio (log scale) |
- Incident CMM by AIP — I2
- 81.2%
Incident CMM by AIP
- AIP showed positive cohort-specific associations
Original publication
Cross-national associations of atherogenic index of plasma and frailty with cardiometabolic multimorbidity: evidence from China, England, and Europe. Diabetes Res Clin Pract. Published 9 November 2026. doi:10.
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