Lipids & metabolic liver disease
Changes in Muscle Mass and the Risk of Liver‐Related Events: A Prospective Cohort Study
Authors' conclusion
Greater preservation or increase in muscle mass was associated with a lower risk of incident LRE, particularly among participants younger than 60 years.
Study context
- Population
- Participants with baseline and first follow-up body composition data; ASM estimated by bioelectrical impedance and Janssen equation, indexed to BMI101 incident liver-related events (LRE)
- Participants
- 19,660 participants
- Exposure
- Tertiles of change in ASM/BMI
- Outcome
- Incident liver-related events (LRE)
- Follow-up
- Median 9.87 years
Main finding
As reported in the abstract
Incident LRE
Each group vs lowest tertileHazard ratio (95% CI)
Intermediate tertile
0.59(0.37–0.94)
Highest tertile
0.44(0.27–0.72)
Observational data: associations, not effects.
Further findings
Incident LRE by age subgroup
- Association more pronounced in participants <60 years
- P for interaction = 0.042
Nonlinear association of ΔASM/BMI with LRE risk (restricted cubic spline)
- P-overall
- P-overall = 0.012
- P-non-linear
- p-non-linear = 0.029
Competing-risk, sensitivity, propensity score-based and nested case-control analyses
- Results generally consistent
Original publication
Changes in Muscle Mass and the Risk of Liver‐Related Events: A Prospective Cohort Study. Diabetes Obes Metab. Published 19 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →