Lipids & metabolic liver disease
Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study
Authors' conclusion
Our findings underscore the positive correlation between the severity of MetS and frailty progression in the middle-aged and elderly, highlighting the urgent need for early identification of MetS and targeted interventions to reduce the risk of frailty.
Study context
- Population
- Middle-aged and elderly adults in China, China Health and Retirement Longitudinal Study (CHARLS) 2011–2018
- Exposure
- Metabolic Syndrome (MetS) severity and frailty progression
- Outcome
- Risk of frailty (frailty index based on 32 health deficits) and FI trajectory
Methodological detailsChina Health and Retirement Longitudinal Study (CHARLS) 2011-2018
- China Health and Retirement Longitudinal Study (CHARLS) 2011-2018
Main finding
As reported in the abstract
Frailty risk, HR per 1 SD increase in MetS score
1.205
95% CI 1.14 to 1.273
Frailty index (FI) trajectory, β per 1 SD increase in MetS score, per year
0.113
95% CI 0.075 to 0.15
Observational data: associations, not effects.
Further findings
Frailty risk and FI trajectory per 1 SD increase in Cumulative MetS score (2012–2015)
- Frailty risk, OR per 1 SD increase (95% CI 1.133 to 1.319); risk increased by 22.2%
- 1.222
- Rate of FI increase, β per year
- 0.098 (95% CI 0.058 to 0.138)
Dose-response (Restricted Cubic Splines (RCS))
- Dose-response curve relationship between MetS score and Cumulative MetS score with frailty risk
Subgroups and interaction
- Stratified analysis showed consistency across subgroups
- In males and individuals aged <60, MetS score may accelerate FI increase, consistent across both models
Original publication
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