Lipids & metabolic liver disease
Association of triglyceride-glucose index and its combination with adiposity-related indices with the incidence of myocardial infarction: a cohort study from the UK Biobank
Authors' conclusion
The TyG index was linearly associated with increased risk of MI and NSTEMI, whereas TyG-BMI, TyG-WC, and TyG-WHtR were nonlinearly associated with increased risk of MI and NSTEMI. There were distinct patterns in the relationships between these indicators with STEMI. TyG-WC provided the best diagnostic effectiveness for MI, STEMI, and NSTEMI.
Study context
- Population
- UK Biobank participants
- Participants
- 370,390 participants
- Exposure
- Highest vs lowest quartiles of triglyceride-glucose (TyG), TyG-BMI, TyG-WC and TyG-WHtR
- Outcome
- Incident MI and its subtypes (STEMI, NSTEMI)
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
TyG, HR
1.36 (1.28-1.44) (95% CI)
TyG-BMI, HR
1.47 (1.39-1.56) (95% CI)
TyG-WC, HR
1.53 (1.43-1.64) (95% CI)
TyG-WHtR, HR
1.58 (1.48-1.68) (95% CI)
Observational data: associations, not effects.
Further findings
ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI)
- Comparable findings for STEMI or NSTEMI; associations of TyG-BMI, TyG-WC and TyG-WHtR with STEMI weaker than with myocardial infarction (MI) and NSTEMI
Dose-response
- Linear dose-response between TyG and risk of MI and NSTEMI
- Nonlinear patterns for TyG-BMI, TyG-WC and TyG-WHtR with MI, STEMI and NSTEMI
Diagnostic performance of TyG-WC (most effective)
- MI, AUC
- 0.648 (0.644-0.653) (95% CI)
- STEMI, AUC
- 0.631 (0.622-0.639) (95% CI)
- NSTEMI, AUC
- 0.647 (0.641-0.654) (95% CI)
Original publication
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