Lipids & metabolic liver disease
Prevalence of Metabolic Dysfunction-associated Steatotic Liver Disease and Cardiometabolic Risk Factor in US Adolescents
Authors' conclusion
The prevalence of MASLD was alarmingly high in adolescents, and overweight/obesity was the most important CMRF. Overweight/obesity and dyslipidemia or elevated glucose had positive additive interaction effects on liver steatosis.
Study context
- Population
- US adolescents aged 12 to 19 years, NHANES 2017 through 2020 cycles
- Outcome
- Prevalence of MASLD
Methodological detailspopulation-based (NHANES 2017–2020)
- Population-based (NHANES 2017–2020)
Main finding
As reported in the abstract
Prevalence of MASLD in adolescents
Prevalence of MASLD
23.77%
Observational data: associations, not effects.
Further findings
Most common CMRF
- Isolated overweight/obesity (top CMRF)
- 35%
- Overweight/obesity plus elevated glucose, highest in non-Hispanic Black
- 24%
- Dyslipidemia burden highest in non-Hispanic Asians
- 2%, 14%, and 19%
Association of cardiometabolic risk factors (CMRFs) with controlled attenuation parameter (CAP)
- Overweight/obesity, β
- 48.7 (95% CI 43.4-54.0)
- Hypertriglyceridemia, β
- 15.5 (95% CI 7.2-28.3)
- Low HDL-C, β
- 10.0 (95% CI 3.1-16.9)
- Elevated glucose, β
- 6.9 (95% CI 0.6-13.2)
- Overweight/obesity + dyslipidemia, β
- 15.1 (95% CI 0.1-30.2)
- Overweight/obesity + dyslipidemia + elevated glucose, β
- 48.0 (95% CI 23.3-72.6)
- Except for hypertension, CMRFs significantly associated with increased CAP
Additive interaction on CAP
- Overweight/obesity × elevated glucose: RERI, AP, SI
- 8.21, 0.45, 1.91
- Overweight/obesity × hypertriglyceridemia: RERI, AP, SI
- 19.00, 0.69, 3.53
- Overweight/obesity × low HDL-C: RERI, AP, SI
- 10.83, 0.58, 2.61
Original publication
Prevalence of Metabolic Dysfunction-associated Steatotic Liver Disease and Cardiometabolic Risk Factor in US Adolescents. J Clin Endocrinol Metab. Published 13 August 2024. doi:10.
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