Lipids & metabolic liver disease
Joint effects of sleep disturbance and renal function impairment on incident new‐onset severe metabolic dysfunction‐associated steatotic liver disease
Main finding · New-onset severe MASLDResult — go to the resultFold higher risk 5.45Authors' conclusion
This study highlights the independent and combined associations of sleep parameters and renal function indicators with new-onset severe MASLD, underscoring the bidirectional communication of the liver-kidney axis and providing modifiable strategies for preventing MASLD.
Study context
- Participants
- 305,257 participants
- Exposure
- Poor sleep patterns and highest RFS vs healthy sleep patterns and lowest RFS
- Outcome
- New-onset severe MASLD
Methodological detailsmultivariable Cox models, traditional mediation analysis, two-step Mendelian randomization
- Multivariable Cox models
- Traditional mediation analysis
- Two-step Mendelian randomization
Main finding
As reported in the abstract
Fold higher risk
5.45
P < 0.001
- Poor sleep score and RFS each associated with increased risk of new-onset severe MASLD
- all ptrend <0.001
Observational data: associations, not effects.
Further findings
Mediation by RFS of poor sleep score–severe MASLD association
- Proportion explained by RFS
- 10.08%
Mendelian randomization (MR) analyses
- MR supported a causal link between insomnia and new-onset severe MASLD, with CKD as a mediator
Original publication
Joint effects of sleep disturbance and renal function impairment on incident new‐onset severe metabolic dysfunction‐associated steatotic liver disease. Diabetes Obes Metab. Published 8 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →