Lipids & metabolic liver disease
Triglyceride-glucose-related indices and cardiovascular outcomes in individuals with pre-frailty or frailty: insights from a prospective cohort analysis using UK Biobank data
Authors' conclusion
TyG-related indices, particularly TyG-WC and TyG-BRI, were independently associated with cardiovascular morbidity and mortality in pre-frail or frail individuals. These indices may serve as simple, scalable tools for identifying cardiovascular risk in pre-frail or frail individuals. Mediation analyses highlight potential avenues for targeted interventions aimed at reducing cardiovascular risk.
Study context
- Population
- Pre-frail or frail individuals without baseline cardiovascular disease (CVD), UK Biobank; median age 57.0 (IQR 49.0, 63.0) years; 54.4% female
- Participants
- 136,004 participants
- Exposure
- Highest vs lowest quartiles of triglyceride-glucose (TyG)-related indices
- Outcome
- Incident CVD and cardiovascular mortality
- Follow-up
- Median 13.3 years
Methodological detailsUK Biobank, Cox proportional hazards models, mediation analyses
- UK Biobank
- Cox proportional hazards models
- Mediation analyses
Main finding
As reported in the abstract
- Participants who developed CVD
- 23,494
Observational data: associations, not effects.
Further findings
Cardiovascular mortality
- Deaths attributed to CVD
- 2453
- Comparable associations were observed for cardiovascular mortality
Dose-response with CVD incidence
- Linear associations for all indices except TyG-BMI and TyG-ABSI (nonlinear)
- P for nonlinearity < 0.01
Incremental predictive value (net reclassification index (NRI), IDI, C-index)
- Significantly improved for all indices; strongest for TyG-WC and TyG-BRI
Mediation
- C-reactive protein, albumin, cystatin C and urate each accounted for observed effects
- more than 10%
Original publication
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