Lipids & metabolic liver disease
Association between the atherogenic index of plasma trajectory and risk of heart failure among hypertensive patients: a prospective cohort study
Authors' conclusion
Prolonged elevation of AIP in hypertensive patients is significantly associated with an increased risk of HF. This finding suggests that regular monitoring of AIP could aid in identifying individuals at a heightened risk of HF within the hypertensive population.
Study context
- Population
- Hypertensive patients from the Kailuan Study with three survey waves 2006–2010, free of heart failure (HF) or cancer before or during 2010822 HF events
- Participants
- 22,201 patients
- Exposure
- Atherogenic index of plasma (AIP) trajectory groups vs low-stable AIP trajectory
- Low-stablen = 3,373reference
- Moderate-low stablen = 12,700
- Moderate-high stablen = 5,313
- Elevated-increasingn = 815
- Outcome
- Incident HF
- Follow-up
- Median 9.98 years
Methodological detailslatent mixed modeling trajectories, Cox proportional hazard models
- Latent mixed modeling trajectories
- Cox proportional hazard models
Main finding
As reported in the abstract
Each group vs low-stableAdjusted hazard ratio (CI)
Elevated-increasing
1.79(1.21,2.66)
Moderate-high stable
1.49(1.17,1.91)
Moderate-low stable
1.27(1.02,1.58)
Observational data: associations, not effects.
Original publication
Association between the atherogenic index of plasma trajectory and risk of heart failure among hypertensive patients: a prospective cohort study. Cardiovasc Diabetol. Published 16 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →