Lipids & metabolic liver disease
Association between the atherogenic index of plasma and incident hypertension across different blood pressure states: a national cohort study
Authors' conclusion
AIP is a significant predictor of hypertension, demonstrating a nonlinear association with its occurrence in normal BP and elevated BP population.
Study context
- Population
- Participants aged ≥45 years in China Health and Retirement Longitudinal Study (CHARLS), assessed 2011 and followed up to 2020, with normal blood pressure (BP) or elevated BP
- Participants
- 6,540 participants
- Exposure
- Higher vs lower atherogenic index of plasma (AIP) for incident hypertension
- Outcome
- Incident hypertension
- Follow-up
- Nine years
Methodological detailsnational, CHARLS data
- National
- CHARLS data
Main finding
As reported in the abstract
over nine years
Developed hypertension
1909
29.19%
AIP and hypertension, normal BP: aOR
1.84
95% CI 1.41–2.39p < 0.001
AIP and hypertension, elevated BP: aOR
1.88
95% CI 1.40–2.52p < 0.001
Observational data: associations, not effects.
Further findings
Predictive ability (ROC)
- AIP had better predictive ability for hypertension than triglycerides (TG) or high-density lipoprotein cholesterol (HDL-C) alone
- Age significantly impacted AIP's predictive value, especially age 45 to 60 in normal BP population
Sensitivity analyses
- Sensitivity analyses validated the nonlinear relationship between AIP and hypertension
Original publication
Association between the atherogenic index of plasma and incident hypertension across different blood pressure states: a national cohort study. Cardiovasc Diabetol. Published 21 May 2025. doi:10.
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