Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population
Authors' conclusion
The AIP exhibits a J-shaped association with the risk of developing T2D. Therefore, maintaining AIP levels below a certain threshold (-0.268) might help prevent the onset of T2D.
Study context
- Population
- Japanese individuals with normal FPG
- Participants
- 15,453 individuals
- Exposure
- Elevated vs lower atherogenic index of plasma (AIP)
- Outcome
- Incident T2D
Main finding
As reported in the abstract
Incident T2D per AIP · average follow-up 6.05 years
Participants developing T2D
373
Elevated AIP and T2D risk, adjusted HR
1.763
95% CI 1.210–2.568P = 0.003
Observational data: associations, not effects.
Further findings
Shape of AIP–T2D association (restricted cubic spline (RCS))
- J-shaped association; sharp increase in risk when AIP exceeded
- - 0.268
Predictability of AIP for new-onset T2D (time-dependent ROC) · 1 to 12 years
- Consistently moderate predictability of AIP for new-onset T2D
Original publication
Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population. Cardiovasc Diabetol. Published 30 January 2025. doi:10.
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