Lipids & metabolic liver disease
Endotoxin biomarkers, hepatic fat fraction, liver volume and liver stiffness among adolescents at high‐risk for non‐alcoholic fatty liver disease: The HEROES study
Authors' conclusion
While additional research is warranted, our results support LBP as a biomarker of NAFLD risk/progression in high-risk youth.
Study context
- Population
- Latino/Latina adolescents (11–19 years) with obesity at high risk for non-alcoholic fatty liver disease (NAFLD)
- Participants
- 99 adolescents
- Exposure
- Endotoxin biomarkers per 1-SD vs liver outcomes
- Outcome
- Associations of LBP and EndoCab (per 1-SD) with hepatic fat fraction (HFF), liver volume and liver stiffness
Methodological detailslinear regression
- Linear regression
Main finding
As reported in the abstract
Associations of endotoxin biomarkers with liver outcomes
Per 1-SD increment in LBP: higher hepatic fat fraction (HFF)
2.35%
adjusted for age, sex, maternal education; 95% CI 0.46%, 4.23%
Per 1-SD increment in LBP: greater liver volume (adjusted; 0.06, 0.23)
0.14 L
Observational data: associations, not effects.
Further findings
LBP associations excluding 72 participants with NAFLD
- Association of LBP with liver volume persisted (per 1-SD; 0.01, 0.21)
- 0.11 L
- Association of LBP with HFF attenuated
Original publication
Endotoxin biomarkers, hepatic fat fraction, liver volume and liver stiffness among adolescents at high‐risk for non‐alcoholic fatty liver disease: The HEROES study. Pediatr Obes. Published 12 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →