Lipids & metabolic liver disease
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism
Authors' conclusion
The data show that serum vaspin is strongly determined by genetic variants within vaspin, which further highlight vaspin's causal role in lipid metabolism.
Study context
- Population
- Participants of six independent cohorts with serum vaspin measured
- Participants
- 7,446 participants6 cohorts
- Outcome
- Genetic variants associated with serum vaspin
Methodological detailssix independent cohorts, Genotype-Tissue Expression (GTEx) gene expression analysis, in vivo db/db mouse experiment
- Six independent cohorts
- GTEx gene expression analysis
- In vivo db/db mouse experiment
Pooled result
As reported in the abstract
Genetic variants within vaspin locus associated with serum vaspin (5 independent variants: rs7141073, rs1956709, rs4905216, rs61978267, rs73338689; all p < 5×10-8)
468
Explained variance
16.8%
Further pooled results
Mendelian randomization (MR): serum vaspin and lipid traits
- Causal relationships between serum vaspin and TG, low-density lipoprotein and total cholesterol
Gene expression correlation (GTEx)
- Genes highly correlated with vaspin expression in adipose tissue enriched in lipid metabolic processes
In vivo vaspin treatment in obese db/db mice
- Vaspin treatment reduced serum TG
Original publication
Genetic dissection of serum vaspin highlights its causal role in lipid metabolism. Obesity (Silver Spring). Published 26 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →